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Unlock Your Potential with Dr. Y.Y.L. Lab

Join us in our efforts to better understand animal physiology and nutrition. Dr. Y.Y.L. Lab is dedicated to exploring the latest insights and innovations in animal health and sustainability research. We believe that our work will ultimately lead to a healthier and more sustainable future.

LAB ACTIVITIES

LAB MEMBERS
 

林原佑 (Y.Y. Lin): P.I.

張倍恩 (P.E. Chang): 國立臺灣大學生物科技所研究生​​

劉憬璇 (C.H. Liu): 國立臺灣大學動物科學技術學系研究所研究生

陳怡廷 (Y.T. Chen): 國立臺灣大學動物科學技術學系研究所研究生

吳文元 (W.Y. Wu): 國立臺灣大學動物科學技術學系研究所研究生

吳昀穎 (Y.Y. Wu): 國立臺灣大學動物科學技術學系研究所研究生

郭立晴 (L.C. Kuo): 國立臺灣大學動物科學技術學系研究所研究生

​​楊雯媛 (W.Y. Yang): 國立臺灣大學動物科學技術學系研究所 (110畢)

Felix Subakti: 國立臺灣大學全球農業科技與基因體科學碩士學位學程 (110畢)

廖珮馨 (P.X. Liao): 國立臺灣大學動物科學技術學系研究所 (109畢)

廖子賢 (T.S. Liao): 國立臺灣大學動物科學技術學系研究所 (109畢)

莊易儒 (Y.R. Zhuang): 東海大學畜產與生物科技學系研究所 (108畢)

學生傑出表現

  • 研究生吳文元獲得財團法人中華扶輪教育基金會2023-2024年度獎學金

  • 研究生劉憬璇獲得2023年 財團法人大成文教基金會勤學獎學金

  • 研究生陳怡廷獲得2023 ARCAP國際研討會最佳演說獎

  • 研究生楊雯媛獲得中國畜牧學會2021年年會學術論文壁報組新人獎

Welcome to the Y.Y.L. Lab Community

PUBLICATIONS

Research and Articles

At Dr. Y.Y.L. Lab., we are passionate about animal physiology and nutrition, with a focus on improving health and enhancing performance. Our research focuses on developing feed additives that promote intestinal health and preventing ferroptosis, a form of cell death that contributes to many diseases. We are dedicated to studying the complexities of animal health and nutrition, with the ultimate goal of improving animal welfare and productivity.

RESEARCH PUBLISHED 研究發表

2024

  1. Yang, W.Y., Chang, P.E., Li, S.J., Ding, S.T., Lin, Y.Y.* Exploring Bile-Acid Changes and Microflora Profiles in Chicken Fatty Liver Disease Model. 2024. Animals, 14(7),992; https://doi.org/10.3390/ani14070992

2023

  1. Yang, W.Y., Chang, P.E., Chen, Y.T., Liao, P.X., Lin, Y.Y.* Taurine-conjugated bile acids are the predominant form in hens and have potential impact on lipid metabolism in the liver. 2023. Italian Journal of Animal Science, 22:1, 1033-1039, DOI: 10.1080/1828051X.2023.2263026

  2. Lin, Y.Y.*, Chang, C.W.T., Takemoto, J.Y. Mesobiliverdin IXα ameliorate DSS-induced colitis by inhibiting inflammation and oxidative stress in mice. 2023. IOP Conference Series: Earth and Environmental Science, 1286 012018

  3. Liao, T.S., Chen, C.Y., Chang, C.W.T., Takamoto, J.Y., Lin, Y.Y.* Mesobiliverdin IXα‐enriched microalgae feed additive eliminates reliance on antibiotic tylosin to promote intestinal health of weaning piglets. 2023. Journal of Animal Physiology and Animal Nutrition, 107 (6), 1368-1375

  4. Lin, Y.Y.*, Chang, P.E., Shen, S.Y., Wang, S.D. Effects of indoor and outdoor rearing system on geese biochemical parameters and cecal microbial composition. 2023. Poultry Science 102:102731. https://doi.org/10.1016/j.psj.2023.102731

  5. Shen, S.Y., Lin, Y.Y., Liao, S.C., Wang, J.S., Wang, S.D., Lien, C.Y.* Effects of phytogenic feed additives on the growth,blood biochemistry, and caecal microorganisms of White Roman geese. 2023. Czech Journal of Animal Science, 68, (5): 202–211. doi:10.17221/205/2022-CJAS 

2013-2022

  1. Zhuang, Y.R., Lin, Y.Y.* Chicken recombinant adiponectin enhances fatty acid metabolism in oleic acid- and palmitic acid-treated LMH cells. 2022. Revista Brasileira de Zootecnia 51:e20220087. doi.org/10.37496/rbz5120220087.

  2. Subakti, F., Chou, C.H., Gozan, M., Lin, Y.Y.* Software-Based Process Simulation and Feasibility Assessment of Black Soldier Fly Larvae Fatty Acid Extraction and Fractionation. 2022. Animals 12 (18), 2349. doi:10.3390/ani12182349.

  3. Lin, Y.Y., Takemoto, J.Y., Chang, C.W.T., Peng, C.A. Mesobiliverdin IXα ameliorates osteoporosis via promoting osteogenic differentiation of mesenchymal stem cells. 2022. Biochem. Biophys. Res. Commun. 619:56-61. doi: 10.1016/j.bbrc.2022.06.042.

  4. Hsu, J.E., Lo, S.H., Lin, Y.Y., Wang, H.T., Chen, C.Y. Effects of essential oil mixtures on nitrogen metabolism and odor emission via in vitro simulated digestion and in vivo growing pig experiments. 2022. J. Sci. Food Agric. 102(5):1939-1947. doi: 10.1002/jsfa.11531.​​

  5. Artdita, C.A., Zhuang, Y.R., Liu, T.Y., Cheng, C.Y., Hsiao, F.S.H.*, Lin, Y.Y.*. The Effect of Feeding Restriction on the Microbiota and Metabolome Response in Late-Phase Laying Hens. 2021. Animals. 11(11): 3043.  

  6. Chien, M.J., Li, S.J., Wong, S.C., Chiang, C.H., Lin, Y.Y., Mersmann, H.J., Chen, C.Y. Determination of mitochondrial functions and damage in kidney in female LeeSung minipigs with a high-fat diet-induced obesity. 2021. Arch Physiol Biochem. doi: 10.1080/13813455.2021.1949022 (Online ahead of print). 

  7. Tzeng, T.R.J., Liu, T.Y., Lin, C.W., Chang, P.E., Liao, P.X., Yang, W.Y., Cheng, C.Y., Liao, P.C., Chiang, W.D., Ding, S.T. and Lin, Y.Y.* Effects of dietary inclusion of dry Hydrastis canadensis on laying performance, egg quality, serum biochemical parameters and cecal microbiota in laying hens. 2021. Animals. 11 (5):1381.

  8. Lin, C.W., Huang, T.W., Peng, Y.J., Lin, Y.Y., Mersmann, H.J., Ding, S.T. A novel chicken model of fatty liver disease induced by high cholesterol and low choline diets. 2021. Poultry Science. 100 (3):100869.

  9. Chen, Y.C., Huang, T.C., Lin, Y.Y.* Expression profile of circulatory adiponectin and plasma variables in broilers. 2021. Braz. J. Poult. Sci. 23 (2) 1-6.

  10. Chang, C.W.T., Takemoto, J.Y., Chang, P.E., Alfindee, M.N., Lin, Y.Y.* Effects of Mesobiliverdin IX alpha-enriched microalgae feed on gut health and microbiota of broilers. 2021. Front. Vet. Sci. 7:586813.

  11. Chen, Y.J., Lin, C.W., Peng, Y.J., Huang, C.W., Chien, Y.S., Huang, T.H., Liao, P.X., Yang, W.Y., Wang, M.H., Mersmann, H.J., Wu, S.C., Chuang, T.Y., Lin, Y.Y.*, Kuo, W.H.*, Ding, S.T.* Overexpression of Adiponectin Receptor 1 Inhibits Brown and Beige Adipose Tissue Activity in Mice. 2021. Int. J. Mol. Sci. 22:E906.​

  12. Lin, Y.Y.*, Dong, Lily Q. APPL1 negatively regulates bone mass, possibly by controlling the fate of bone marrow mesenchymal progenitor cells. 2020. Proc Jpn Acad Ser B Phys Biol Sci. 96 (8): 364-371.

  13. Lin, C.W., Peng, Y.J., Lin, Y.Y., Mersmann HJ, Ding ST. LRRK2 regulates CPT1A to promote β-oxidation in HepG2 cells. 2020. Molecules. 25 (18): 4122​

  14. Chen, C.Y., Chen, Y.J., Ding, S.T., Lin, Y.Y.* Expression profile of adiponectin and adiponectin receptors in high-fat diet feeding chickens. 2018. J Anim Physiol Anim Nutr (Berl). 102 (6): 1585-1592.

  15. Lin, Y.Y., Chen, C.Y., Ding, S.T. Adiponectin receptor 1 resists the decline of serum osteocalcin and GPRC6A expression in ovariectomized mice. 2017. PLoS ONE. 12(12): e0189063.

  16. Wang, S.H., Lin, H.J., Lin, Y.Y., Chen, Y.J., Pan, Y.H., Tung, C.T., Mersmann, H.J., Ding, S.T. Embryonic cholesterol esterification is regulated by a cyclic AMP-dependent pathway in yolk sac membrane-derived endodermal epithelial cells. 2017. PLoS ONE. 12 (11): e0187560.

  17. Liu, H.Y., Chen, C.C., Lin, Y.Y., Chen, Y.J., Liu, B.H., Wong, S.C., Wu, C.Y., Chang, Y.T., Chou, H.Y., Ding, S.T. Chitosan-assisted differentiation of porcine adipose tissue-derived stem cells into glucose-responsive insulin-secreting clusters. 2017. PLoS ONE. 12(3): e0172922.

  18. Lin, H.J., Chen, Y.S., Chen, Y.J., Lin, Y.Y, Mersmann HJ, Ding ST. Modulation of fatty acid oxidation and glucose uptake by oxytocin in adipocytes. 2017. Journal of Biomedical Science and Engineering. 10:37-50.

  19. Mai, T.N.T., Hamada, M., Nakamura, M., Jeon, H., Kamei, R., Tsunakawa, Y., Kulathunga, K., Lin, Y.Y., Fujisawa, K., Kudo, T., Takahashi, S. MafB deficiency accelerates the development of obesity in mice. 2016. FEBS Open Bio. 6:540-547.

  20. Lin, Y.Y., Chen, C.Y., Chuang, T.Y., Lin, Y., Liu, H.Y., Mersmann, H.J., Wu, S.C., Ding, S.T. Adiponectin receptor 1 regulates bone formation and osteoblast differentiation by GSK-3β/β-catenin signaling in mice. 2014. Bone. 64: 147-154.

  21. Lin, Y.Y., Chen, C.Y., Chen, C.C., Lin, H.J., Mersmann, H.J., Wu, S.C., Ding, S.T. The effects of adiponectin on bone metabolism. 2014. J. Biomedical Science and Engineering. 7: 621-630.

  22. Chou, I.P., Lin, Y.Y,, Ding. S.T., Chen, C.Y. Adiponectin receptor 1 enhances fatty acid metabolism and cell survival in palmitate-treated HepG2 cells through the PI3 K/AKT pathway. 2014. Eur J Nutr. 53: 907-917.

  23. Lin, H.Y., Chen, C.C., Chen, Y.J., Lin, Y.Y., Mersmann, H.J., Ding, S.T. Enhanced amelioration of high-fat diet-induced fatty liver by docosahexaenoic acid and lysine supplementations. 2014. Biomed Res Int. http://dx.doi.org/10.1155/2014/310981.

  24. Chou, I.P., Chiu, Y.P., Ding, S.T., Liu, B.H., Lin, Y.Y., Chen, C.Y. Adiponectin receptor 1 overexpression reduces lipid accumulation and hypertrophy in the heart of diet-induced obese mice - possible involvement of oxidative stress and autophagy. 2014. Endocr Res. 39: 173-179.

  25. Lin, Y.Y., Chen, C.Y., Lin, Y., Pang, C.Y., Chen, C.C., Liu, B.H., Mersmann, H.J., Wu, S.C., Mersmann, H.J. and Ding, S.T. Modulation of glucose and lipid metabolism by porcine adiponectin receptor 1-transgenic mesenchymal stem cells in diet-induced obese mice. 2013. Cytotherapy. 15: 971-978.

  26. Liu, B.H., Lin, Y.Y,, Wang, Y.C., Huang, C.W., Chen, C.C., Wu, S.C., Mersmann, H.J., Cheng, W.T.K. and Ding, S.T. Porcine adiponectin receptor 1 transgene resists high fat/sucrose diet-induced obesity and insulin resistance in mice. 2013. Experimental Animal 62: 347-360.

EXPLORING THE UNKNOWN 研究方向

  1. The emerging role of ferroptosis in intestinal health

  2. Alternative of antibiotics in animal production

  3. To elucidate the role of novel adipokines in chicken

研究計畫

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開發含膽綠素相似物之螺旋藻萃取物應用於飼料添加以改善動物腸道健康

2019.08.01-2021.01.31

The global livestock industry is entering a new era. In response to the global trend of phasing out antibiotic growth promoters, investing in research and development of alternative additives has become an important issue. Gut inflammatory bowel diseases (IBDs) are costly and serious diseases in the livestock industry. Possible links between animal IBDs, medicinal feed for livestock, and the antibiotic-resistance threat to the public health are fueling major economic impacts in agriculture. New animal feeds that promote livestock gut health and control IBDs without antibiotics are needed. Previous studies shown that rich nutrients of algae are suitable for feed additive, but the regulatory mechanism of inflammation and anti-microbial activity still unclear. The proposed research seeks to explore the possibility of a new category of livestock feed devoid of antibiotics and that could promote animal gut health and reduce IBDs. It exploits recent discoveries on mesobiliverdin, an analog of the animal metabolite biliverdin known to protect against IBDs and new synthetic strategies for producing it from kilogram (kg) amounts of microalgae. The research is basic and multidisciplinary but has the singular focus of eventual development of a nextgeneration animal feed.

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利用實驗動物模式驗證並篩選可以有效調整腸胃功能與免疫調節之先導動物 保健飼料添加劑

2018.06.01-2021.05.31

本計畫總體目標希望從臺灣特有藥用植物、天然物、微生物及其衍生物篩選出有效之動物保健 飼料添加劑，藉此提高飼養動物對不良環境的抵抗與保護能力，或是提升飼料利用率並降低飼 養與治療成本。

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Ferroptosis_edited.jpg

含膽綠素相似物之螺旋藻改善鐵依賴型細胞死亡媒介之雞隻腸炎

2022.08.01~
2023.07.31

鐵依賴型細胞死亡（ferroptosis）為新型態的細胞死亡模式，與細胞內鐵之代謝、 脂肪過氧化和氧化壓力等因素有關，近期研究顯示動物的各種腸道疾病可能與此種 型態的細胞死亡模式有關，且雞隻的壞死性腸炎亦是肉雞產業發達國家的重要問題 ，本研究計畫的執行能夠藉由瞭解鐵的代謝與雞隻腸炎的關係，並由鐵依賴型細胞 死亡的角度來改善雞隻腸炎，並從中發現腸炎發生時潛在的未知因子，作為臨床診 斷的參考依據。

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COLLABORATORS

Prof. Tom Chang
Utah State Univ., U.S.

Prof. Jon Takemoto
Utah State Univ., U.S.

Dr. Anuraga Jayanegara
IPB UNIV., INDONESIA.

Dr. Chuan-Shuen Lin
Agricultural Technology Research Institute​

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